Where CVS Really Fits Your Day Across South Carolina

A 10 pm passport photo downtown, a 2 am refill steps from the Strand, a clinic visit on a Sunday afternoon before school sports start. That is how CVS shows up across South Carolina right now, with a footprint that is less about a single mega-store and more about a network you can tap differently in Myrtle Beach, Columbia, Greenville, Rock Hill and the Lowcountry. CVS Health lists 213 locations statewide, so the trick is knowing which stores deliver which conveniences when you actually need them.

Start with the store that rarely says no to the clock. At 1303 38th Ave N, Myrtle Beach, the location’s store and pharmacy both run 24 hours, and the pharmacy notes a lunch pause from 1:30–2 pm. This one also lists a MinuteClinic on site and a UPS Access Point for packages. If you only remember one late-night address for beach weeks, this is it. Photo services here track regular CVS Photo pricing statewide, including passport photos at $17.99 for two prints, and same-day 4x6 prints typically 42¢ each for 1–99 or 32¢ each at 100+ when you order for in-store pickup.

Columbia looks different depending on which part of town you land in. The downtown store at 900 Assembly St, Columbia keeps the retail side open 24 hours but the pharmacy closes nightly at 8 pm, so it is the better bet for urgent toiletries or late photo pickup rather than a midnight antibiotic. That same address houses a MinuteClinic with posted day schedules that commonly run 8:30 am–7:30 pm most weekdays and a clinic lunch 1:30–2:30 pm. Out in the northeast, 121 Clemson Rd, Columbia is a later-hour suburban play, with the store posted to close at 11 pm and drive‑thru pharmacy service during pharmacy hours; that site also ties into the MinuteClinic network.

Where CVS clusters in South Carolina right now

The chain’s pattern in the state mirrors daily life. Coastal tourism drives 24-hour options in Horry County. University and government schedules keep a downtown retail door open in Columbia even when its dispensary window is shut. Upstate growth shows up in Greenville’s corridor stores that combine drive‑thru, immunizations and photo under one roof. And bedroom communities around Charlotte rely on a Rock Hill address with expanded care features.

Two details help you navigate across cities:

• MinuteClinic’s posted price for sports physicals is $82 at South Carolina clinics as of late summer 2026. If your child’s school uses a standard form, bring it with you; clinics handle these seven days a week at sites including 2707 Celanese Rd, Rock Hill, 121 Clemson Rd, Columbia, and several others.
• CVS Photo’s everyday pricing travels with you: passport photos $17.99, and in-store 4x6 prints priced per the same pickup schedule above. That is handy when you are replacing a lost passport photo set after hours downtown or printing camp forms in Greenville before drop-off.

Greenville’s 3901 Pelham Rd store is a typical Upstate mix. It lists a MinuteClinic, photo center, immunizations, and a drive‑thru, with the pharmacy often posted to close at 8 pm on weekdays. If you are planning a clinic visit after work, keep an eye on that clinic closing window, which frequently shows 7:30 pm on day-of listings in the app.

Services that make CVS a shopping errand, not just a pharmacy

Photo and ID services you can plan around

If your week hinges on paperwork and prints more than refills, CVS’s photo counter is one of the state’s most predictable in-store services. Across South Carolina locations, CVS lists passport photos at $17.99 for a set of two. Same-day prints are equally standardized: order 4x6 prints for 42¢ each when buying 1–99, or 32¢ each when you order 100+ in the same pickup. Stores with robust photo counters include downtown Columbia at 900 Assembly St, beachside at 1303 38th Ave N, and Greenville’s Pelham Road address. For last-minute travel paperwork, the combination of retail hours and standardized pricing is why many locals treat CVS as the default.

MinuteClinic as a predictable slot in the week

When you do not need a full primary care appointment, MinuteClinic fills a niche. In South Carolina, MinuteClinic pages post a flat $82 for sports physicals with payment by card, cash or check. Most clinics list seven-day schedules and often run to 7:30 pm on weekdays, with a midday lunch break. You see this clearly at 900 Assembly St, Columbia, where weekday clinic hours are posted at 8:30 am–7:30 pm with a 1:30–2:30 pm pause. Rock Hill’s 2707 Celanese Rd shows the same service mix and is also designated on its store page as a HealthHUB, meaning more floor space for health and wellness items and on-site support that goes beyond the classic drugstore aisle mix.

Vaccines and the seasonality of errands

Flu, COVID-19 and other routine vaccinations run through pharmacy and MinuteClinic schedules. Most South Carolina plans bill shots directly. If you are paying cash for add-ons like a passport photo in the same trip, the checkout line and the immunization line are separate, which can save time when the store is busy. In Columbia’s downtown location, for instance, the retail floor stays open all night while pharmacy immunization hours follow the pharmacy’s closing at 8 pm.

Late-night and last-minute: which CVS actually stays open

This matters during storms, beach weeks, tournament weekends and finals. Here are four addresses that behave differently from one another and cover the use cases most people ask about.

If you prefer West Ashley, another pattern to watch is the cluster along Savannah Highway and Sam Rittenberg Boulevard. Those stores trade 24-hour clocks for drive‑thru access and photo pickup until 10 pm most nights. If all you need is a prepaid pickup or prints, it can be faster than crossing town to a 24-hour site.

What ExtraCare and ExtraCare Plus change at checkout

CVS now runs two stacked programs. The free tier is ExtraCare, which tracks purchases and returns 2% back in ExtraBucks Rewards on qualifying items. The paid tier is ExtraCare Plus, which the company prices at $5 per month or $48 per year when you enroll annually. The paid plan is more than coupons. It explicitly includes free delivery of eligible prescriptions, free same-day delivery for everyday items where service is available, and an ongoing 20% off eligible CVS Health brand products in store and online. Members also receive a $10 monthly bonus reward that you can spend on most non-excluded items.

In practice around South Carolina, ExtraCare Plus changes two errands. First, if you expect to be on the road during a refill window, free Rx delivery as a member means you do not have to drive to Pelham Road or 38th Avenue North to hit the pharmacy hours. Second, if you print photos or stock up on CVS Health brand items regularly, the 20% brand discount combines with the flat-rate photo prices statewide. The member benefits do not override state or insurer rules, and delivery availability or item eligibility varies, so check your store page in the app before you bank on same-day arrival.

The more basic advantage that matters for families is simply being able to line up a clinic slot and a prescription pickup in the same building. Because most South Carolina pharmacies, including 24-hour ones, list a 1:30–2 pm pharmacist lunch break, this is the window that most commonly catches people out. If you are timing a MinuteClinic visit to get a sports physical at $82 and fill a prescription after, plan your arrival either before lunch starts or after it ends. The 24-hour pharmacies in Rock Hill and Myrtle Beach still observe that pause at the pharmacy counter even while the front store stays open.

When the difference between stores is a single service

All four example stores in this guide run photo centers and immunizations, and three run MinuteClinic rooms. The differences that nudge you one way or the other are small but concrete:

• If the pharmacy has to be open overnight, go to 1303 38th Ave N, Myrtle Beach or 2707 Celanese Rd, Rock Hill, both with 24-hour pharmacy service listed.
• If you need retail shopping or photo pickup after midnight downtown, 900 Assembly St, Columbia keeps the store open all night while the pharmacy closes at 8 pm.
• If you want clinic plus drive‑thru in the Upstate before dinner, 3901 Pelham Rd, Greenville fits the pattern with clinic schedules that frequently show 7:30 pm weekday closes.

Key things to know before you go

• The statewide MinuteClinic price for sports physicals is $82. Clinics post seven-day schedules and commonly run until 7:30 pm on weekdays, with a lunch pause mid-afternoon. Plan around that if you want a same-day exam and a pickup.
• Photo pricing is predictable. Passport photos are $17.99, and same-day 4x6 prints are 42¢ each for 1–99 prints or 32¢ at 100+, which makes a big family batch cheaper if you consolidate.
• ExtraCare Plus membership is $5/month or $48/year and includes free delivery of eligible prescriptions and a $10 monthly reward. It also lists 20% off eligible CVS Health brand items, which stacks well with weekly deals.
• Many South Carolina CVS pharmacies list a 1:30–2 pm lunch break even at 24-hour sites. If you have a tight window, check the store’s page in the app to avoid standing in a pharmacy line that is temporarily closed.
• Two addresses solve the true late-night problem: 1303 38th Ave N, Myrtle Beach and 2707 Celanese Rd, Rock Hill, both listing store and pharmacy 24 hours.

Reader Q&A

Which CVS in South Carolina is actually open all night for both store and pharmacy?

The most reliable examples are 1303 38th Ave N, Myrtle Beach and 2707 Celanese Rd, Rock Hill. Both list the store and the pharmacy as 24 hours, with the pharmacy observing a 1:30–2 pm lunch pause. If you only need retail late at night in Columbia, 900 Assembly St keeps the store open 24 hours while its pharmacy closes at 8 pm.

How much will a MinuteClinic sports physical cost in South Carolina?

MinuteClinic posts $82 statewide for sports physicals. Clinics run seven days at many stores and often show a 7:30 pm weekday close with a lunch break. You can use sites such as 121 Clemson Rd, Columbia, 2707 Celanese Rd, Rock Hill, and 3901 Pelham Rd, Greenville, then handle pharmacy pickup at the same address.

Is ExtraCare Plus worth it for deliveries, or should I just do in-store pickup?

ExtraCare Plus is $5/month or $48/year and includes free delivery of eligible prescriptions, free same-day delivery for everyday items where available, a $10 monthly reward, and 20% off eligible CVS Health brand items. If you already use print pickup or run frequent small errands, in-store pickup remains fast, but the membership removes delivery fees and can save trips during busy weeks.

Where should I go for late photo or ID needs in the Midlands?

Head to 900 Assembly St, Columbia for 24-hour retail access. You can get passport photos for $17.99 and same-day prints priced at 42¢/32¢ tiers even when the pharmacy is closed. If you also need a clinic visit or a prescription, plan earlier in the day or choose a site where the pharmacy is 24 hours.

Published: September 9, 2026